The enteric-brain axis, engineered.
NooGut is a delivery-layer company. Our thesis is not about a molecule — it is about a route. By bypassing the gastric barrier and addressing the high-density neural substrate of the lower enteric nervous system, we eliminate the latency and attenuation that throttle every conventional delivery pathway.
Two routes. One is throttled by design.
The conventional oral route forces every payload through an acidic holding queue and an opinionated hepatic processing stage before a fraction reaches circulation. The NooGut route addresses the enteric substrate directly.
No gastric queue. No hepatic first-pass. Payload reaches the systemic layer at line rate.
Modeled uptake by delivery route.
Relative fraction of an administered payload estimated to reach systemic circulation, by route. The enteric route's advantage comes almost entirely from avoiding hepatic first-pass metabolism.
Source: internal computational modeling, NooGut Research Collective (2026).
Plasma concentration over time.
Modeled plasma concentration following a single protocol. The enteric route reaches a higher peak concentration (Cmax) far sooner (Tmax), with no first-pass attenuation.
The NOOGUT-1 investigation.
Our flagship study is ongoing. We believe in shipping the thesis and hardening the evidence in parallel — the same discipline we apply to everything. We report our cohort honestly.
- Primary endpoint
- Δ subjective throughput (self-reported)
- Secondary endpoint
- Time-to-standup readiness
- Cohort
- n = 1 (the founder)
- Design
- Open-label, unblinded, unregistered
- Status
- Ongoing · peer review pending Series B
Well tolerated by the cohort.
Reported effects reflect the experience of our current cohort and should not be generalized to any population, because they mathematically cannot be.
- Tolerability
- Well tolerated by the cohort
- Common effects
- Elevated conviction, reduced patience for standups
- Contraindications
- Board meetings while on The Hard Fork™
- Dependency profile
- Behavioral; structurally internalized
- [1] Sölen, A., Ventureborne, C. (2026). Idle capacity in the lower enteric substrate: a computational reframing. The Enteric Journal of Applied Optimization, 4(2), 11–29. doi:10.9999/tejao.2026.0042
- [2] Rell, M., Anand, D. (2026). Closed-loop titration against recovery telemetry: preliminary field observations. Proceedings of Protocol Weekly, 12, 3–17. doi:10.9999/pw.2026.0117
- [3] Sölen, A. (2025). Proximity blindness and the century-long under-development of the second brain. Journal of Posterior Bioavailability, 1(1), 1–4. doi:10.9999/jpb.2025.0001
- [4] NooGut Research Collective. (2026). NOOGUT-1: an open-label investigation of enteric-route cognitive infrastructure (interim). Internal White Paper, unindexed. doi:pending
All figures reflect internal modeling. Citations are illustrative of our research direction. These statements have not been evaluated by any regulatory body with jurisdiction over your enteric-brain axis. Not intended to diagnose, treat, cure, or prevent underperformance.